2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. HCN Channel
  5. HCN Channel Inhibitor

HCN Channel Inhibitor

HCN Channel Inhibitors (9):

Cat. No. Product Name Effect Purity
  • HY-101346
    ZD7288
    		Inhibitor 99.94%
    ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.
  • HY-B0162A
    Ivabradine hydrochloride
    		Inhibitor 99.61%
    Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity.
  • HY-18940A
    Cilobradine hydrochloride
    		Inhibitor ≥99.0%
    Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.
  • HY-160505
    RO-275
    		Inhibitor ≥99.0%
    RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder.
  • HY-B0162
    Ivabradine
    		Inhibitor
    Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity.
  • HY-161092
    KIO-301 chloride
    		Inhibitor
    KIO-301 chloride is an azobenzene photoswitch compound that can block voltage-gated ion channels, including hyperpolarisation-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium channels during exposure to visible light.
  • HY-163455
    pan-HCN-IN-1
    		Inhibitor
    pan-HCN-IN-1 (Compound J&J12e) is an inhibitor for hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with IC50 of 58 nM. pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rats brain slices.
  • HY-161092A
    KIO-301 chloride (hydrochloride)
    		Inhibitor 99.61%
    KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels).
  • HY-B0162AR
    Ivabradine hydrochloride (Standard)
    		Inhibitor
    Ivabradine (hydrochloride) (Standard) is the analytical standard of Ivabradine (hydrochloride). This product is intended for research and analytical applications. Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity.